From: <b class="gmail_sendername">Gopal Dabade</b> <span dir="ltr"><<a href="mailto:drdabade@gmail.com">drdabade@gmail.com</a>></span><br><div class="gmail_quote"><br><br><p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif""><a href="http://pharmabiz.com/NewsDetails.aspx?aid=67408&sid=1" target="_blank"><span style="color:windowtext">http://pharmabiz.com/NewsDetails.aspx?aid=67408&sid=1</span></a></span></p>
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<p class="MsoNormal"><b><span style="font-family:'Times New Roman',serif"><font size="4"><br></font></span></b></p><p class="MsoNormal"><b><span style="font-family:'Times New Roman',serif"><font size="4">Planning Commission panel calls for sterner regime
on FDCs</font><font size="3"></font></span></b></p>
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<p class="MsoNormal" style="margin-bottom:0.0001pt"><b><i><span style="font-size:12.0pt;font-family:"Times New Roman","serif"">Joseph Alexander, New Delhi</span></i></b><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><br>
<i>Wednesday, February 08, 2012, 08:00 Hrs [IST]</i></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman","serif"">Even as the industry is still
discontent with the authorities on the issue of Fixed Dose Combinations
(FDCs), an expert panel of the Planning Commission has called for stricter
criteria for registration and regulatory review of FDCs by the Central Drugs
Standard Control Organisation (CDSCO) with a view to weed out irrational
FDCs.<br>
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“Irrational FDCs, non-essential vitamins/tonics, cough syrups feature in the
top selling pharmaceuticals in terms of value and volume but they harm public
health and patients by increasing adverse effects, imposing higher financial
burden on patients and facilitating - emergence of drug resistance (in the
case of FDCs of antibiotics). Therefore, stricter criteria for registration
and - regulatory review of medicines by CDCSO should be a priority. This
helps weed out substandard, toxic, irrational medicines from the market,” a
working group of the Commission said.<br>
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It suggested that CDSCO should implement a much stricter registration regime
for FDCs. Products should be selected and approved only when the combination
has a proven advantage in therapeutic effect, safety, adherence or in
decreasing the emergence of drug resistance in malaria, tuberculosis and
HIV/AIDS, the panel said.<br>
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“Except FDCs included in the WHO’s essential Drug List, all FDCs registered
in India are reviewed in terms of their therapeutic effect and legally
sustainable action taken for phased out weeding of all irrational FDCs. The
Drug Technical Advisory Board should set up a suitable mechanism for the
purpose,” it said.<br>
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FDCs have been at the centre of a vexed controversy for over four years now.
The lack of concrete rules largely led to the confusion and confrontation
between the authorities and the industry, after the DCGI sought to weed out
the irrational FDCs from the market.</span></p><span class="HOEnZb"><font color="#888888">
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